Vol 6: Beyond humanization and de-immunization: tolerization as a method for reducing the immunogenicity of biologics.Report as inadecuate



 Vol 6: Beyond humanization and de-immunization: tolerization as a method for reducing the immunogenicity of biologics.


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This article is from Expert Review of Clinical Pharmacology, volume 6.AbstractImmune responses to some monoclonal antibodies (mAbs) and biologic proteins interfere with their efficacy due to the development of anti-drug antibodies (ADA). In the case of mAbs, most ADA target ‘foreign’ sequences present in the complementarity determining regions

Author: De Groot, Anne S; Terry, Frances; Cousens, Leslie; Martin, William

Source: https://archive.org/







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