Vol 27: Acceleration of an aldo-keto reductase by minimal loop engineering.Report as inadecuate



 Vol 27: Acceleration of an aldo-keto reductase by minimal loop engineering.


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This article is from Protein Engineering, Design and Selection, volume 27.AbstractAldo-keto reductases tighten coenzyme binding by forming a hydrogen bond across the pyrophosphate group of NAD(P)(H). Mutation of the hydrogen bonding anchor Lys24 in Candida tenuis xylose reductase prevents fastening of the -safety belt- around NAD(H). The loosened N

Author: Krump, C.; Vogl, M.; Brecker, L.; Nidetzky, B.; Kratzer, R.

Source: https://archive.org/







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