Vol 9: A Synthetic Manassantin A Derivative Inhibits Hypoxia-Inducible Factor 1 and Tumor Growth.Report as inadecuate



 Vol 9: A Synthetic Manassantin A Derivative Inhibits Hypoxia-Inducible Factor 1 and Tumor Growth.


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This article is from PLoS ONE, volume 9.AbstractThe dineolignan manassantin A from Saururaceae was recently identified as a hypoxia-inducible factor 1 (HIF-1) inhibitor, but its in-vivo anti-tumor effect has not been explored.
We synthesized a series of manassantin A derivatives, and found that replacing the central tetrahydrofuran moiety with a cy

Author: Lang, Liwei; Liu, Xiaoyu; Li, Yan; Zhou, Qing; Xie, Ping; Yan, Chunhong; Chen, Xiaoguang

Source: https://archive.org/