An Application of a Self-consistent Mean-Field Theoretical Model to POPC-PSM-Cholesterol Bilayers - Condensed Matter > Mesoscale and Nanoscale PhysicsReport as inadecuate




An Application of a Self-consistent Mean-Field Theoretical Model to POPC-PSM-Cholesterol Bilayers - Condensed Matter > Mesoscale and Nanoscale Physics - Download this document for free, or read online. Document in PDF available to download.

Abstract: The connection between membrane inhomogeneity and the structural basis oflipid rafts has sparked interest in the lateral organization of model lipidbilayers of two and three components. In an effort to investigate anisotropiclipid distribution in mixed bilayers, a self-consistent mean-field theoreticalmodel is applied to palmitoyloleoylphosphatidylcholine POPC - palmitoylsphingomyelin PSM - Cholesterol mixtures. The compositional dependence oflateral organization in these mixtures is mapped onto a ternary plot. The modelutilizes molecular dynamics simulations to estimate interaction parameters andto construct chain conformation libraries. We find that at some concentrationratios the bilayers separate spatially into regions of higher and lower chainorder coinciding with areas enriched with PSM and POPC respectively. To examinethe effect of the asymmetric chain structure of POPC on bilayer lateralinhomogeneity, we consider POPC-POPC interactions with and without angulardependence. Results are compared with experimental data and with results from asimilar model for mixtures of dioleoylphosphatidylcholine DOPC, steroylsphingomyelin, and Cholesterol.



Author: Paul Tumaneng, Sagar A. Pandit, Guijun Zhao, H. L. Scott

Source: https://arxiv.org/







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