Cyclic Hypervalent Iodine Reagents and Iron Catalysts: The Winning Team for Late-Stage C-H AzidationReport as inadecuate




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Published in: Angewandte Chemie-International Edition (ISSN: 1433-7851), vol. 54, num. 18, p. 5290-5292 Weinheim: Wiley-Blackwell, 2015

1+1=3: by combining the exceptional properties of benziodoxolone reagents and iron catalysts, Sharma and Hartwig have achieved an important breakthrough for the late-stage C-Hazidation of complex molecules. Nevertheless, moderate yields and selectivities were still observed for some substrates, and our understanding of the reaction mechanism remains underdeveloped. Indeed, the potential of combining base-metal catalysts and cyclic hypervalent iodine reagents for the discovery of new reactions has just begun to be investigated, and many more exciting discoveries await us in the future. © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Keywords: azides ; C-H functionalization ; hypervalent iodine ; iron catalysis ; radicals Reference EPFL-ARTICLE-212674doi:10.1002/anie.201501666View record in Web of Science





Author: Vita, Maria Victoria; Waser, Jerome

Source: https://infoscience.epfl.ch/record/212674?ln=en







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