Platinum-Catalyzed Domino Reactionwith Benziodoxole Reagents for Accessing Benzene-Alkynylated IndolesReport as inadecuate




Platinum-Catalyzed Domino Reactionwith Benziodoxole Reagents for Accessing Benzene-Alkynylated Indoles - Download this document for free, or read online. Document in PDF available to download.

Published in: Angewandte Chemie-International Edition (ISSN: 1433-7851), vol. 54, num. 18, p. 5438-5442 Weinheim: Wiley-Blackwell, 2015

Indoles are omnipresent in natural products, bioactive molecules, and organic materials. Consequently, their synthesis or functionalization are important fields of research in organic chemistry. Most works focus on installation or modification of the pyrrole ring. To access benzene-ringfunctionalized indoles with an unsubstituted pyrrole ring remains more challenging. Reported herein is a platinumcatalyzed cyclization/alkynylation domino process to selectively obtain C5-or C6-functionalized indoles starting from easily available pyrroles. The work combines, for the first time, a platinum catalyst with ethynylbenziodoxole hypervalent iodine reagents in a domino process for the synthesis of polyfunctionalized arene rings and gives access to important building blocks for the synthesis of bioactive compounds and organic materials.

Keywords: alkynes ; cyclization ; heterocycles ; hypervalent compounds ; platinum Reference EPFL-ARTICLE-212675doi:10.1002/anie.201412321View record in Web of Science





Author: Li, Yifan; Waser, Jerome

Source: https://infoscience.epfl.ch/record/212675?ln=en



DOWNLOAD PDF




Related documents