MHC-dependent inhibition of uterine NK cells impedes fetal growth and decidual vascular remodellingReport as inadecuate


MHC-dependent inhibition of uterine NK cells impedes fetal growth and decidual vascular remodelling


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Publication Date: 2014-02-28

Journal Title: Nature Communications

Publisher: Nature Publishing Group

Volume: 5

Number: 3359

Language: English

Type: Article

This Version: VoR

Metadata: Show full item record

Citation: Kieckbusch, J., Gaynor, L. M., Moffett, A., & Colucci, F. (2014). MHC-dependent inhibition of uterine NK cells impedes fetal growth and decidual vascular remodelling. Nature Communications, 5 (3359)https://doi.org/10.1038/ncomms4359

Description: This is the final version of the article. It first appeared from Nature Publishing Group at http://dx.doi.org/10.1038/ncomms4359.

Abstract: NK cells express variable receptors that engage polymorphic MHC class I molecules and regulate their function. Maternal NK cells accumulate at the maternal-fetal interface and can interact with MHC class I molecules from both parents. The relative contribution of the two sets of parental MHC molecules to uterine NK cell function is unknown. Here we show that, in mice, maternal and not paternal MHC educates uterine NK cells to mature and acquire functional competence. The presence of an additional MHC allele that binds more inhibitory than activating NK cell receptors results in suppressed NK cell function, compromised uterine arterial remodelling and reduced fetal growth. Notably, reduced fetal growth occurs irrespectively of the parental origin of the inhibitory MHC. This provides biological evidence for the impact of MHC-dependent NK inhibition as a risk factor for human pregnancy-related complications associated with impaired arterial remodelling.

Sponsorship: This work was supported by the Wellcome Trust, the Medical Research Council, the Centre for Trophoblast Research and the British Heart Foundation.

Identifiers:

External DOI: https://doi.org/10.1038/ncomms4359

This record's URL: https://www.repository.cam.ac.uk/handle/1810/260343



Rights: Attribution-NonCommercial-NoDerivatives 4.0 International

Licence URL: http://creativecommons.org/licenses/by-nc-nd/4.0/





Author: Kieckbusch, JensGaynor, Louise M.Moffett, AshleyColucci, Francesco

Source: https://www.repository.cam.ac.uk/handle/1810/260343



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