Longitudinal assessment of global and regional atrophy rates in Alzheimers disease and dementia with Lewy bodiesReport as inadecuate


Longitudinal assessment of global and regional atrophy rates in Alzheimers disease and dementia with Lewy bodies


Longitudinal assessment of global and regional atrophy rates in Alzheimers disease and dementia with Lewy bodies - Download this document for free, or read online. Document in PDF available to download.

Publication Date: 2015-02-07

Journal Title: NeuroImage: Clinical

Publisher: Elsevier

Volume: 7

Pages: 456-462

Language: English

Type: Article

Metadata: Show full item record

Citation: Mak, E., Su, L., Williams, G. B., & Watson, R. (2015). Longitudinal assessment of global and regional atrophy rates in Alzheimer's disease and dementia with Lewy bodies. NeuroImage: Clinical, 7 456-462.

Description: This is the final published version. It first appeared at http://www.sciencedirect.com/science/article/pii/S2213158215000182#.

Abstract: Background & objective Percent whole brain volume change (PBVC) measured from serial MRI scans is widely accepted as a sensitive marker of disease progression in Alzheimer's disease (AD). However, the utility of PBVC in the differential diagnosis of dementia remains to be established. We compared PBVC in AD and dementia with Lewy bodies (DLB), and investigated associations with clinical measures. Methods 72 participants (14 DLBs, 25 ADs, and 33 healthy controls (HCs)) underwent clinical assessment and 3 Tesla T1-weighted MRI at baseline and repeated at 12 months. We used FSL-SIENA to estimate PBVC for each subject. Voxelwise analyses and ANCOVA compared PBVC between DLB and AD, while correlational tests examined associations of PBVC with clinical measures. Results AD had significantly greater atrophy over 1 year (1.8%) compared to DLB (1.0%; p = 0.01) and HC (0.9%; p < 0.01) in widespread regions of the brain including periventricular areas. PBVC was not significantly different between DLB and HC (p = 0.95). There were no differences in cognitive decline between DLB and AD. In the combined dementia group (AD and DLB), younger age was associated with higher atrophy rates (r = 0.49, p < 0.01). Conclusions AD showed a faster rate of global brain atrophy compared to DLB, which had similar rates of atrophy to HC. Among dementia subjects, younger age was associated with accelerated atrophy, reflecting more aggressive disease in younger people. PBVC could aid in differentiating between DLB and AD, however its utility as an outcome marker in DLB is limited.

Keywords: Dementia, Alzheimer's disease, Lewy bodies, Neuroimaging, Atrophy

Sponsorship: This work was supported by the Sir Jules Thorn Charitable Trust (grant number 05/JTA), the NIHR Biomedical Research Unit in Dementia and the Biomedical Research Centre awarded to Cambridge University Hospitals NHS Foundation Trust and the University of Cambridge, and the NIHR Biomedical Research Unit in Dementia and the Biomedical Research Centre awarded to Newcastle upon Tyne Hospitals NHS Foundation Trust and the Newcastle University. Elijah Mak was in receipt of a Gates Cambridge, PhD studentship.

Identifiers:

This record's URL: http://dx.doi.org/10.1016/j.nicl.2015.01.017http://www.repository.cam.ac.uk/handle/1810/247509

Rights: Attribution-NonCommercial-NoDerivs 2.0 UK: England & Wales

Licence URL: http://creativecommons.org/licenses/by-nc-nd/2.0/uk/





Author: Mak, ElijahSu, LiWilliams, Guy B.Watson, Rosie

Source: https://www.repository.cam.ac.uk/handle/1810/247509



DOWNLOAD PDF




Related documents