Glutamate signalling: A multifaceted modulator of oligodendrocyte lineage cells in health and diseaseReport as inadecuate


Glutamate signalling: A multifaceted modulator of oligodendrocyte lineage cells in health and disease


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Publication Date: 2016-06-23

Journal Title: Journal of Neuropharmacology

Publisher: Elsevier

Language: English

Type: Article

This Version: AM

Metadata: Show full item record

Citation: Spitzer, S., Volbracht, K., Lundgaard, I., & Káradóttir, R. T. (2016). Glutamate signalling: A multifaceted modulator of oligodendrocyte lineage cells in health and disease. Journal of Neuropharmacology https://doi.org/10.1016/j.neuropharm.2016.06.014

Description: This is the author accepted manuscript. The final version is available from Elsevier via http://dx.doi.org/10.1016/j.neuropharm.2016.06.014

Abstract: Myelin is essential for the mammalian brain to function efficiently. Whilst many factors have been associated with regulating the differentiation of oligodendroglia and myelination, glutamate signalling might be particularly important for learning-dependent myelination. The majority of myelinated projection neurons are glutamatergic. Oligodendrocyte precursor cells receive glutamatergic synaptic inputs from unmyelinated axons and oligodendrocyte lineage cells express glutamate receptors which enable them to monitor and respond to changes in neuronal activity. Yet, what role glutamate plays for oligodendroglia is not fully understood. Here, we review glutamate signalling and its effects on oligodendrocyte lineage cells, and myelination in health and disease. Furthermore, we discuss whether glutamate signalling between neurons and oligodendroglia might lay the foundation to activity-dependent white matter plasticity.

Keywords: oligodendrocyte, myelination, remyelination, glutamate, oligodendrocyte precursor cell, neuronal activity, proliferation, differentiation

Sponsorship: Lister Institute of Preventive Medicine: Ragnhildur Thóra Káradóttir and Sonia Spitzer; Wellcome Trust: Ragnhildur Thóra Káradóttir 091543/Z/10/Z; Medical Research Council: Katrin Volbracht: DTG RG64862; Sonia Spitzer: 1004208.

Identifiers:

External DOI: https://doi.org/10.1016/j.neuropharm.2016.06.014

This record's URL: https://www.repository.cam.ac.uk/handle/1810/256741



Rights: Attribution-NonCommercial-NoDerivatives 4.0 International

Licence URL: http://creativecommons.org/licenses/by-nc-nd/4.0/





Author: Spitzer, SoniaVolbracht, KatrinLundgaard, IbenKáradóttir, Ragnhildur T.

Source: https://www.repository.cam.ac.uk/handle/1810/256741



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