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Abstract: Most models designed to study the bidirectional movement of cargos as theyare driven by molecular motors rely on the idea that motors of differentpolarities can be coordinated by external agents if arranged into a motor-cargocomplex to perform the necessary work gross04. Although these models haveprovided us with important insights into these phenomena, there are still manyunanswered questions regarding the mechanisms through which the movement of thecomplex takes place on crowded microtubules. For example i how doescargo-binding affect motor motility? and in connection with that - ii howdoes the presence of other motors and also other cargos on the microtubuleaffect the motility of the motor-cargo complex? We discuss these questions froma different perspective. The movement of a cargo is conceived here as a hoppingprocess resulting from the transference of cargo between neighboring motors. Inthe light of this, we examine the conditions under which cargo might displaybidirectional movement even if directed by motors of a single polarity. Theglobal properties of the model in the long-time regime are obtained by mappingthe dynamics of the collection of interacting motors and cargos into anasymmetric simple exclusion process ASEP which can be resolved using thematrix ansatz introduced by Derrida Derrida et al.



Author: Carla Goldman

Source: https://arxiv.org/







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