A concise and scalable strategy for the total synthesis of dictyodendrin B based on sequential C–H functionalizationReport as inadecuate


A concise and scalable strategy for the total synthesis of dictyodendrin B based on sequential C–H functionalization


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Publication Date: 2015-02-23

Journal Title: Angewandte Chemie International Edition

Publisher: Wiley

Volume: 54

Pages: 5451-5455

Language: English

Type: Article

Metadata: Show full item record

Citation: Pitts, A. K., O'Hara, F., Snell, R. H., & Gaunt, M. J. (2015). A concise and scalable strategy for the total synthesis of dictyodendrin B based on sequential C–H functionalization. Angewandte Chemie International Edition, 54 5451-5455.

Description: This is the author accepted manuscript. The final version is available from Wiley at http://onlinelibrary.wiley.com/doi/10.1002/anie.201500067/abstract.

Abstract: A sequential C-H functionalization strategy for the synthesis of the marine alkaloid dictyodendrin B is reported. Our synthesis begins from commercially available 4-bromoindole and involves six direct functionalizations around the heteroarene core as part of a gram-scale strategy towards the natural product.

Keywords: C-H functionalization, flow chemistry, metal catalysis, natural products, total synthesis

Sponsorship: We are grateful to AstraZeneca, Pfizer, and EPSRC (A.K.P., F.O. and R.H.S.) and the ERC and EPSRC for fellowships (M.J.G.).

Identifiers:

This record's URL: http://dx.doi.org/10.1002/anie.201500067http://www.repository.cam.ac.uk/handle/1810/248954





Author: Pitts, Andrew K.O-Hara, FionnSnell, Robert H.Gaunt, Matthew J.

Source: https://www.repository.cam.ac.uk/handle/1810/248954



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