Vol 9: Incidence and Geographical Variation of Amyotrophic Lateral Sclerosis ALS in Southern Germany - Completeness of the ALS Registry Swabia.Report as inadecuate



 Vol 9: Incidence and Geographical Variation of Amyotrophic Lateral Sclerosis ALS in Southern Germany - Completeness of the ALS Registry Swabia.


Vol 9: Incidence and Geographical Variation of Amyotrophic Lateral Sclerosis ALS in Southern Germany - Completeness of the ALS Registry Swabia. - Download this document for free, or read online. Document in PDF available to download.

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This article is from PLoS ONE, volume 9.AbstractObjective of this paper was to investigate the incidence, potential geographical clusters and the completeness of the amyotrophic lateral sclerosis ALS registry in Southern Germany Swabia.Age-standardized incidence rates ASR and ratios SIR as well as 95% confidence intervals CI were estimated at county level. Capture-recapture CARE procedures were applied taking data source dependency into account to estimate the quality of case ascertainment in the ALS registry Swabia. We identified 438 ALS cases 53% men, 47% women in the target population of about 8.4 Mio inhabitants. The gender ratio men∶women was 1.1∶1. The mean age at onset of ALS was 63.8 SD = 11.9 years for men and 66.0 12.2 for women. The age distribution peaked in the age group 70–74 years. The ASR of ALS was 2.5 per 100,000 person years PY; 95% CI: 2.3–2.7. The mean SIR was 1.1 per 100,000 PY 95% CI: 1.0–1.2. High SIR suggesting geographical clusters were observed in two counties Göppingen and Bodenseekreis, but the variation was not statistically significant p-values = 0.2 and 0.5. The percentage of CARE estimated missing cases was 18.9% in the registry yielding an ASR of 3.1 per 100,000 PY. The high coverage of the CARE estimated completeness of the ALS registry Swabia indicates excellent quality for future projects. Regional variations have to be investigated further.



Author: Uenal, Hatice; Rosenbohm, Angela; Kufeldt, Johannes; Weydt, Patrick; Goder, Katharina; Ludolph, Albert; Rothenbacher, Dietrich; Nagel, Gabriele

Source: https://archive.org/







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