Vol 31: Inter- and Intraspecies Phylogenetic Analyses Reveal Extensive X-Y Gene Conversion in the Evolution of Gametologous Sequences of Human Sex Chromosomes.Report as inadecuate



 Vol 31: Inter- and Intraspecies Phylogenetic Analyses Reveal Extensive X-Y Gene Conversion in the Evolution of Gametologous Sequences of Human Sex Chromosomes.


Vol 31: Inter- and Intraspecies Phylogenetic Analyses Reveal Extensive X-Y Gene Conversion in the Evolution of Gametologous Sequences of Human Sex Chromosomes. - Download this document for free, or read online. Document in PDF available to download.

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This article is from Molecular Biology and Evolution, volume 31.AbstractIt has long been believed that the male-specific region of the human Y chromosome MSY is genetically independent from the X chromosome. This idea has been recently dismissed due to the discovery that X–Y gametologous gene conversion may occur. However, the pervasiveness of this molecular process in the evolution of sex chromosomes has yet to be exhaustively analyzed. In this study, we explored how pervasive X–Y gene conversion has been during the evolution of the youngest stratum of the human sex chromosomes. By comparing about 0.5 Mb of human–chimpanzee gametologous sequences, we identified 19 regions in which extensive gene conversion has occurred. From our analysis, two major features of these emerged: 1 Several of them are evolutionarily conserved between the two species and 2 almost all of the 19 hotspots overlap with regions where X–Y crossing-over has been previously reported to be involved in sex reversal. Furthermore, in order to explore the dynamics of X–Y gametologous conversion in recent human evolution, we resequenced these 19 hotspots in 68 widely divergent Y haplogroups and used publicly available single nucleotide polymorphism data for the X chromosome. We found that at least ten hotspots are still active in humans. Hence, the results of the interspecific analysis are consistent with the hypothesis of widespread reticulate evolution within gametologous sequences in the differentiation of hominini sex chromosomes. In turn, intraspecific analysis demonstrates that X–Y gene conversion may modulate human sex-chromosome-sequence evolution to a greater extent than previously thought.



Author: Trombetta, Beniamino; Sellitto, Daniele; Scozzari, Rosaria; Cruciani, Fulvio

Source: https://archive.org/







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