Vol 65: 149 HCV AND lymphoma: Genetic and epigenetic factors.Report as inadecuate



 Vol 65: 149 HCV AND lymphoma: Genetic and epigenetic factors.


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This article is from Journal of Acquired Immune Deficiency Syndromes (1999), volume 65.AbstractOver 180 million people worldwide are chronically infected with the hepatitis C virus (HCV). HCV infection is a major cause for hepatocellular carcinoma (HCC), moreover the association with B-cell lymphoproliferative disorders (LPDs) like mixed cryoglobulinemia (MC) or B-cell non-Hodgkin lymphoma (B-NHL) is undisputed.The mechanisms by which HCV contributes to LPD development are still poorly understood. Available data suggest that the viral infection may induce LPDs through a multifactorial and multistep process that involves the sustained activation of B cells, the abnormal and prolonged B cell survival, and genetic and-or epigenetic factors.Concerning genetic factors, different authors reported an association between specific HLA clusters or B-cell activating factor promoter genotype and a higher risk of developing MC and lymphoma. In addition, the results of a large, ongoing genome wide association study (GWAS) will probably allow the identification of specific genetic profile of HCV patients with LPDs.Furthermore, microRNAs (miRNAs) can give a major contribution to the pathogenesis of several neoplastic, lymphoproliferative diseases and it is conceivable their involvement in the pathogenesis of HCV-related LPDs.We recently showed that specific miRNAs were differently modulated in PBMCs from HCV patients who developed MC and-or NHL. In addition, HCV patients who developed HCC, showed a differential miRNAs regulation.In conclusion, available data suggest that the genetic-epigenetic analysis of HCV-related cancerogenesis is of great usefulness in both the pathogenetic and clinical-translational areas possibly allowing the definition of diagnostic-prognostic markers for early detection of lymphatic or hepatic cancer.



Author: Zignego, AL; Gragnani, L; Fognani, E; Piluso, A

Source: https://archive.org/



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