Vol 11: Gadd45a levels in human breast cancer are hormone receptor dependent.Report as inadecuate



 Vol 11: Gadd45a levels in human breast cancer are hormone receptor dependent.


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This article is from Journal of Translational Medicine, volume 11.AbstractBackground: Gadd45a is a member of the Gadd45 family of genes that are known stress sensors. Gadd45a has been shown to serve as an effector in oncogenic stress in breast carcinogenesis in murine models. The present study was aimed at clarifying the expression of Gadd45a in human breast cancer and its correlation with clinicopathologic features. Methods: The expression levels of Gadd45a in breast tissue samples of female breast surgery cases were examined by immunohistochemistry (IHC) using a Gadd45a antibody. Percent staining was determined and statistical analyses were applied to determine prognostic correlations. Results: 56 female breast surgery cases were studied: Normal (11), Luminal A (9), Luminal B (11), HER2+ (10), Triple Negative (15). There was a highly significant difference in percent Gadd45a staining between groups Mean: Normal 16.3%; Luminal A 65.3%; Luminal B 80.7%; HER2+ 40.5%; TN 32%, P 



Author: Tront, Jennifer S; Willis, Alliric; Huang, Yajue; Hoffman, Barbara; Liebermann, Dan A

Source: https://archive.org/







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