Vol 8: Gating charge movement precedes ionic current activation in hERG channels.Report as inadecuate



 Vol 8: Gating charge movement precedes ionic current activation in hERG channels.


Vol 8: Gating charge movement precedes ionic current activation in hERG channels. - Download this document for free, or read online. Document in PDF available to download.

Download or read this book online for free in PDF: Vol 8: Gating charge movement precedes ionic current activation in hERG channels.
This article is from Channels, volume 8.AbstractWe recently reported gating currents recorded from hERG channels expressed in mammalian TSA cells and assessed the kinetics at different voltages. We detected 2 distinct components of charge movement with the bulk of the charge being carried by a slower component. Here we compare our findings in TSA cells with recordings made from oocytes using the Cut Open Vaseline Gap clamp (COVG) and go on to directly compare activation of gating charge and ionic currents at 0 and +60 mV. The data show that gating charge saturates and moves more rapidly than ionic current activates suggesting a transition downstream from the movement of the bulk of gating charge is rate limiting for channel opening.



Author: Goodchild, Samuel J; Fedida, David

Source: https://archive.org/



DOWNLOAD PDF




Related documents