Vol 4: Genomic methylation patterns in archaeological barley show de-methylation as a time-dependent diagenetic process.Report as inadecuate



 Vol 4: Genomic methylation patterns in archaeological barley show de-methylation as a time-dependent diagenetic process.


Vol 4: Genomic methylation patterns in archaeological barley show de-methylation as a time-dependent diagenetic process. - Download this document for free, or read online. Document in PDF available to download.

Download or read this book online for free in PDF: Vol 4: Genomic methylation patterns in archaeological barley show de-methylation as a time-dependent diagenetic process.
This article is from Scientific Reports, volume 4.AbstractGenomic methylation is variable under biotic and abiotic stresses in plants. In particular, viral infection is thought to significantly increase genomic methylation with particularly high activity around transposable elements. Here we present the genomic methylation profiles of grains of archaeological barley (Hordeum vulgare) from several strata from a site in southern Egypt, from the Napatan to the Islamic periods (800 BCE – 1812 CE). One sample tested positive for viral infection and exhibits an unusually high degree of genomic methylation compared to the rest. A decreasing trend in global methylation levels according to deposition date shows in-situ de-methylation of 5-methylcytosine, which can be described as a diagenetic process. This is most likely a deamination mediated de-methylation process and is expected to lead to 5 mC > T base modifications in addition to the C > U modifications due to cytosine deamination, so represents a time-dependent process of DNA diagenesis in ancient DNA.



Author: Smith, Oliver; Clapham, Alan J.; Rose, Pam; Liu, Yuan; Wang, Jun; Allaby, Robin G.

Source: https://archive.org/



DOWNLOAD PDF




Related documents