Efficient one pot nitro reduction-protection of y-nitro aliphatic methyl esters Report as inadecuate




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Jaime Escalante ;Journal of the Mexican Chemical Society 2009, 53 (3)

Author: Francisco D. Díaz-Coutiño

Source: http://www.redalyc.org/


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Journal of the Mexican Chemical Society ISSN: 1870-249X editor.jmcs@gmail.com Sociedad Química de México México Díaz-Coutiño, Francisco D.; Escalante, Jaime Efficient One Pot Nitro Reduction-Protection of y-Nitro Aliphatic Methyl Esters Journal of the Mexican Chemical Society, vol.
53, núm.
3, julio-septiembre, 2009, pp.
93-95 Sociedad Química de México Distrito Federal, México Available in: http:--www.redalyc.org-articulo.oa?id=47512154003 How to cite Complete issue More information about this article Journals homepage in redalyc.org Scientific Information System Network of Scientific Journals from Latin America, the Caribbean, Spain and Portugal Non-profit academic project, developed under the open access initiative J.
Mex.
Chem.
Soc.
2009, 53(3), 93-95 © 2009, Sociedad Química de México ISSN 1870-249X Article Efficient ‘One Pot’ Nitro Reduction-Protection of γ-Nitro Aliphatic Methyl Esters Francisco D.
Díaz-Coutiño and Jaime Escalante* Centro de Investigaciones Químicas, Universidad Autónoma del Estado de Morelos.
Av.
Universidad No.
1001, Col.
Chamilpa, C.P.
62210 Cuernavaca, Mor., México.
Tel.: 52 (777) 3 29 79 97; fax: 52 (777) 3 29 79 98; e-mail: jaime@ciq.uaem.mx. Dedicated to Prof.
Ernest Eliel 1921-2008 Received Febrary 27, 2009; accepted May 28, 2009 Abstract.
A simple and efficient protocol has been developed for the direct conversion of γ-nitro aliphatic methyl esters to N-(tertbutoxycarbonyl)amine methyl esters using NH4 HCO2- and Pd-C in the presence of (Boc)2O.
There was a significant decrease in the reaction time under these conditions, increased yields and the purity of the products using this ‘one pot’ procedure. Keywords: ‘One-pot’ reaction, γ-nitro reduction, N-Boc-amino protection. Resumen.
Un protocolo simple y eficiente de síntesis ha sido desarrollado para la conversión directa de metil ésteres de γ-nitro alifáticos a N-(tert-butoxicarbonil)amina metil ésteres empleando NH4 HCO2- y Pd-C en ...





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