Molecular modeling study of 2-substituted isoindoline derivatives of a-amino acids as inhibitors of lipoxygenase by docking simulations Report as inadecuate




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José Correa Basurto ; Karla S. Alavés Carbajal ; Nagchielli Valle-Sandoval ; José Trujillo Ferrara ;Journal of the Mexican Chemical Society 2009, 53 (1)

Author: Teresa Mancilla Percino

Source: http://www.redalyc.org/


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Journal of the Mexican Chemical Society ISSN: 1870-249X editor.jmcs@gmail.com Sociedad Química de México México Mancilla Percino, Teresa; Correa Basurto, José; Alavés Carbajal, Karla S.; Valle-Sandoval, Nagchielli; Trujillo Ferrara, José Molecular Modeling Study of 2-Substituted Isoindoline Derivatives of a-Amino Acids as Inhibitors of Lipoxygenase by Docking Simulations Journal of the Mexican Chemical Society, vol.
53, núm.
1, enero-marzo, 2009, pp.
1-6 Sociedad Química de México Distrito Federal, México Available in: http:--www.redalyc.org-articulo.oa?id=47512075001 How to cite Complete issue More information about this article Journals homepage in redalyc.org Scientific Information System Network of Scientific Journals from Latin America, the Caribbean, Spain and Portugal Non-profit academic project, developed under the open access initiative Article J.
Mex.
Chem.
Soc.
2009, 53(1), 1-6 © 2009, Sociedad Química de México ISSN 1870-249X Molecular Modeling Study of 2-Substituted Isoindoline Derivatives of a-Amino Acids as Inhibitors of Lipoxygenase by Docking Simulations Teresa Mancilla Percino,*1 José Correa Basurto,2,3,4 Karla S.
Alavés Carbajal,2 Nagchielli Valle-Sandoval,2 and José Trujillo Ferrara2,3,4 1 Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional, Departamento de Química.
Apartado Postal 14-740, CP 07000, México, D.
F.
México.
tmancill@cinvestav.mx 2 Instituto Politécnico Nacional, Escuela Superior de Medicina, Sección de Estudios de Posgrado e Investigación 3 Departamento de Bioquímica, 4Departamento de Farmacología.
Plan de San Luis y Díaz Mirón s-n Col.
Casco de Santo Tomás, Delegación Miguel Hidalgo, C.
P.
11340, México, D.
F. Received October 24, 2008; accepted January 23, 2009 Abstract.
In this work two series of isoindolines 1(a-g) and 2(a-g) were evaluated as possible inhibitors of lipoxygenase (LOX) by docking studies, as well as for the antiinflammatories isoindolilami...





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