Electrochemical reduction of 2-nitroimidazole in aprotic medium: Influence of its dissociation equilibrium on the reduction mechanismReport as inadecuate




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The electrochemical reduction of 2-nitroimidazole in a non-aqueous medium using cyclic voltammetry CV at a mercury electrode was carried out.The 2-nitroimidazole derivative in DMF + 0.1 M tetran-butylammonium hexafluorophosphate TBAHFP6 resulted in the following dissociation equilibrium:HNRNO2 reversible arrow -NRNO, + H+The neutral species HNRNO2 and the corresponding conjugate base -NRNO2 are characterized by UV absorption bands at 328 and 370 nm, respectively.The voltammograms of 2-nitroimidazole produced two well-defined signals, which were determined by the above dissociation equilibrium. The first reduction peak was caused by the reduction of the neutral species according to the following overall mechanism:5HNRNO2 + 4e-> 4-NRNO2 + HNRNHOH + H2OThe second quasi-reversible couple was caused by the reduction of the conjugate base according to the following equation:-NRNO2 + e-> NRNO2 center dot-



Author: Squella Serrano, Juan; - Campero, A.; - Maraver, J.; - Carbajo, J.; -

Source: http://repositorio.uchile.cl/



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