Effect of heme oxygenase–endogenous carbon monoxide on mortality during septic shock in ratsReport as inadecuate




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Irish Journal of Medical Science

, 178:491

First Online: 04 December 2008Received: 26 March 2008Accepted: 31 October 2008DOI: 10.1007-s11845-008-0260-x

Cite this article as: Yu, J. & Yao, S. Ir J Med Sci 2009 178: 491. doi:10.1007-s11845-008-0260-x

Abstract

AimTo investigate the effect of HO–CO on mortality during septic shock in rats.

MethodEighty rats were randomly divided into group-control, group ZnPP-IX, group SS, and group LZ.

ResultsDeath was significantly lower in group SS than in group LZ P < 0.05. The MAP was significantly higher in the group LZ than in the group SS P < 0.05. ALT, AST, Cr and BUN, MDA, and the lung EB contents, were significantly lower in the group SS than that in the group LZ all P < 0.05. And CO and SOD activities were significantly higher in group SS than that in the group LZ all P < 0.05. HO-1 mRNA, and HO-1 protein were significantly lower in the group LZ than in the group SS P < 0.05, whereas HO-2 mRNA, and HO-2 protein were not significantly different among four groups all P > 0.05.

ConclusionThe increased oxidative stress and end-organ damage is related to mortality during septic shock; while the hypotension partly contributing to HO-1 protein and CO has no obvious relation with it.

KeywordsSeptic shock Heme oxygenase Carbon monoxide Hypotension Mortality  Download fulltext PDF



Author: J.-b. Yu - S.-l. Yao

Source: https://link.springer.com/







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