Comparative myogenesis in teleosts and mammalsReport as inadecuate

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Cellular and Molecular Life Sciences

, Volume 71, Issue 16, pp 3081–3099

First Online: 25 March 2014Received: 28 October 2013Revised: 17 February 2014Accepted: 06 March 2014DOI: 10.1007-s00018-014-1604-5

Cite this article as: Rossi, G. & Messina, G. Cell. Mol. Life Sci. 2014 71: 3081. doi:10.1007-s00018-014-1604-5


Skeletal myogenesis has been and is currently under extensive study in both mammals and teleosts, with the latter providing a good model for skeletal myogenesis because of their flexible and conserved genome. Parallel investigations of muscle studies using both these models have strongly accelerated the advances in the field. However, when transferring the knowledge from one model to the other, it is important to take into account both their similarities and differences. The main difficulties in comparing mammals and teleosts arise from their different temporal development. Conserved aspects can be seen for muscle developmental origin and segmentation, and for the presence of multiple myogenic waves. Among the divergences, many fish have an indeterminate growth capacity throughout their entire life span, which is absent in mammals, thus implying different post-natal growth mechanisms. This review covers the current state of the art on myogenesis, with a focus on the most conserved and divergent aspects between mammals and teleosts.

KeywordsMouse and zebrafish Myotome and dermomyotome Primary and secondary myogenesis Muscle fiber types Satellite cells Regeneration  Download fulltext PDF

Author: Giuliana Rossi - Graziella Messina


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