Comprehensive Biomarker Testing of Glycemia, Insulin Resistance, and Beta Cell Function Has Greater Sensitivity to Detect Diabetes Risk Than Fasting Glucose and HbA1c and Is Associated with Improved Glycemic Control in Clinical PrReport as inadecuate




Comprehensive Biomarker Testing of Glycemia, Insulin Resistance, and Beta Cell Function Has Greater Sensitivity to Detect Diabetes Risk Than Fasting Glucose and HbA1c and Is Associated with Improved Glycemic Control in Clinical Pr - Download this document for free, or read online. Document in PDF available to download.

Journal of Cardiovascular Translational Research

, Volume 7, Issue 6, pp 597–606

First Online: 29 July 2014Received: 27 March 2014Accepted: 15 July 2014DOI: 10.1007-s12265-014-9577-1

Cite this article as: Varvel, S.A., Voros, S., Thiselton, D.L. et al. J. of Cardiovasc. Trans. Res. 2014 7: 597. doi:10.1007-s12265-014-9577-1

Abstract

Blood-based biomarker testing of insulin resistance IR and beta cell dysfunction may identify diabetes risk earlier than current glycemia-based approaches. This retrospective cohort study assessed 1,687 US patients at risk for cardiovascular disease CVD under routine clinical care with a comprehensive panel of 19 biomarkers and derived factors related to IR, beta cell function, and glycemic control. The mean age was 53 ± 15, 42 % were male, and 25 % had glycemic indicators consistent with prediabetes. An additional 45 % of the patients who had normal glycemic indicators were identified with IR or beta cell abnormalities. After 5.3 months of median follow-up, significantly more patients had improved than worsened their glycemic status in the prediabetic category 35 vs. 9 %; P < 0.0001 and in the -high normal- category HbA1c values of 5.5–5.6; 56 vs. 18 %, p < 0.0001. Biomarker testing can identify IR early, enable and inform treatment, and improve glycemic control in a high proportion of patients.

KeywordsDiabetes risk Biomarker Insulin resistance Glycemic control Beta cell function Associate Editor Enrique Lara-Pezzi oversaw the review of this article

Electronic supplementary materialThe online version of this article doi:10.1007-s12265-014-9577-1 contains supplementary material, which is available to authorized users.

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Author: Stephen A. Varvel - Szilard Voros - Dawn L. Thiselton - James V. Pottala - Tara Dall - G. Russell Warnick - Joseph P. 

Source: https://link.springer.com/







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