The impact of microRNA-mediated PI3K-AKT signaling on epithelial-mesenchymal transition and cancer stemness in endometrial cancerReport as inadecuate




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Journal of Translational Medicine

, 12:231

Cell, tissue and gene therapy

Abstract

Activation of the PI3K-AKT pathway, a common mechanism in all subtypes of endometrial cancers endometrioid and non-endometrioid tumors, has important roles in contributing to epithelial-mesenchymal transition EMT and cancer stem cell CSC features. MicroRNAs miRNAs are small non-coding RNA molecules that concurrently affect multiple target genes, and regulate a wide range of genes involved in modulating EMT and CSC properties. Here we overview the recent advances revealing the impact of miRNAs on EMT and CSC phenotypes in tumors including endometrial cancer via regulating PI3K-AKT pathway. MiRNAs are crucial mediators of EMT and CSC through targeting PTEN-PI3K-AKT-mTOR axis. In endometrial cancer cells, miRNAs can activate or attenuate EMT and CSC by targeting PTEN and other EMT-associated genes, such as Twist1, ZEB1 and BMI-1. More detailed studies of miRNAs will deepen our understanding of the molecular basis underlying PI3K-AKT-induced endometrial cancer initiation and progression. Targeting key signaling components of PI3K-AKT pathway by restoring or inhibiting miRNA function holds promise as a potential therapeutic approach to suppress EMT and CSC in endometrial cancer.

KeywordsMicrorna PI3K PTEN AKT mTOR EMT Invasion Cancer stem cell Chemoresistance Endometrial cancer Electronic supplementary materialThe online version of this article doi:10.1186-s12967-014-0231-0 contains supplementary material, which is available to authorized users.

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Author: Peixin Dong - Yosuke Konno - Hidemichi Watari - Masayoshi Hosaka - Masayuki Noguchi - Noriaki Sakuragi

Source: https://link.springer.com/



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