Hyaluronidase: from clinical applications to molecular and cellular mechanismsReport as inadecuate




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European Journal of Medical Research

, 21:5

First Online: 13 February 2016Received: 04 November 2015Accepted: 05 February 2016DOI: 10.1186-s40001-016-0201-5

Cite this article as: Buhren, B.A., Schrumpf, H., Hoff, NP. et al. Eur J Med Res 2016 21: 5. doi:10.1186-s40001-016-0201-5

Abstract

Over the past 60 years, hyaluronidase has been successfully utilized in ophthalmic surgery and is now being implemented in dermatosurgery as well as in other surgical disciplines. The enzyme is considered a -spreading factor- as it decomplexes hyaluronic acid also called hyaluronan, HA, an essential component of the extracellular matrix ECM. When applied as an adjuvant, hyaluronidase enhances the diffusion capacity and bioavailability of injected drugs. Therefore, the enzyme has been used as a local adjuvant to increase the diffusion capacity of local anesthetics, increasing the analgesic efficacy, and the anesthetized area particularly in the first minutes following injection, resulting in diminished intra- and postoperative pain. In aesthetic medicine, the off-label use of hyaluronidase is considered the gold standard for the management of HA-filler-associated complications. Here, we review the clinical use, underlying biological mechanisms, and future directions for the application of hyaluronidase in surgical and aesthetic medicine.

KeywordsHyaluronidase Hyaluronic acid Hyaluronan Filler Dermatosurgery Aesthetic dermatology Adjuvant Spreading effect Diffusion promotor  Download fulltext PDF



Author: Bettina Alexandra Buhren - Holger Schrumpf - Norman-Philipp Hoff - Edwin Bölke - Said Hilton - Peter Arne Gerber

Source: https://link.springer.com/







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