An Experimental Study to Replace the Thoracic Descending Aorta for Pigs with a Self-Made Sutureless Blood VesselReport as inadecuate




An Experimental Study to Replace the Thoracic Descending Aorta for Pigs with a Self-Made Sutureless Blood Vessel - Download this document for free, or read online. Document in PDF available to download.

BioMed Research International - Volume 2014 2014, Article ID 587393, 7 pages -

Research Article

Department of the Cardiovascular Surgery of the 2nd Xiangya Hospital, Central South University, Middle Renmin Road 139, Changsha 410011, China

Department of the Cardiovascular Surgery of the Hunan Provincial People’s Hospital, Middle Jiefang Road 61, Changsha 410005, China

Received 2 December 2013; Accepted 6 January 2014; Published 18 February 2014

Academic Editor: Ali AbuRahma

Copyright © 2014 Fenglin Song et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

To simplify the procedure of blood vessel replacement operation and shorten the vascular anastomosis time, we developed a special artificial blood vessel which can be connected to native blood vessels without suture. The self-made sutureless blood vessel SMSBV was made from two titanium connectors and a Gore-Tex graft. To investigate blood compatibility and histocompatibility of the SMSBV, we carried thoracic descending aorta replacement using either SMSBV or Gore-Tex, respectively, in pigs. The aortic clamp time and the operative blood loss in the experimental group using SMSBV were less than those in the control group using Gore-Tex. The whole blood hematocrit, platelet count, plasma soluble P-selectin, plasma free hemoglobin, and interleukins 2, 6 at each time point were not different significantly between the two groups. Light microscopy and transmission electron microscopy examination showed there were layers of vascular smooth muscle cells and endothelial cells adhered in the inner wall of artificial blood vessel without any signs of thrombosis. Based on the result, we have drawn the conclusion that the application of SMSBV can significantly shorten the vascular anastomosis time, reduce operative blood loss, and show good blood and tissue compatibility.





Author: Fenglin Song, Wenwu Zhou, Tao Tang, Xiaobing Li, Xiaoming Wu, and Jinfu Yang

Source: https://www.hindawi.com/



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