High nuclear-cytoplasmic ratio of Cdk1 expression predicts poor prognosis in colorectal cancer patientsReport as inadecuate




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BMC Cancer

, 14:951

Translational oncology

Abstract

BackgroundCdk1 cyclin-dependent kinase 1 is critical regulator of the G2-M checkpoint. Cyclin-dependent kinase pathways are considered possible targets for cancer treatment; however, the prognostic role of Cdk1 in colorectal cancer is still controversial. Therefore, we attempted to determine the impact of Cdk1 on the clinical outcome of colorectal cancer patients to further identify its role in colorectal cancer.

MethodsCdk1 immunoreactivity was analyzed by immunohistochemistry IHC in 164 cancer specimens from primary colorectal cancer patients. The medium follow-up time after surgery was 3.7 years range: 0.01 to 13.10 years. The prognostic value of Cdk1 on overall survival was determined by Kaplan-Meier analysis and Cox proportional hazard models.

ResultsAll samples displayed detectable Cdk1 expression with predominant location in the cytoplasm and nucleus. A high Cdk1 nuclear-cytoplasmic N-C expression ratio was correlated with poor overall survival 5-year survival rate: 26.3% vs 46.9%, N-C ratio ≥1.5 vs N-C ratio <1.5, log-rank p = 0.027. Accordingly, a Cdk1 N-C expression ratio ≥1.5 was identified as an independent risk factor by multivariate analysis hazard ratio = 1.712, P = 0.039.

ConclusionsWe suggest that Cdk1 N-C expression ratio determined by IHC staining could be an independent prognostic marker for colorectal cancer.

KeywordsCyclin-dependent kinase 1 Prognosis Colorectal cancer Electronic supplementary materialThe online version of this article doi:10.1186-1471-2407-14-951 contains supplementary material, which is available to authorized users.

Wen-Wei Sung, Yueh-Min Lin contributed equally to this work.

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Author: Wen-Wei Sung - Yueh-Min Lin - Pei-Ru Wu - Hsu-Heng Yen - Hung-Wen Lai - Tzu-Cheng Su - Ren-Hung Huang - Chun-Kai Wen - Chi

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