Underexpression of Deleted in liver cancer 2 DLC2 is associated with overexpression of RhoA and poor prognosis in hepatocellular carcinomaReport as inadecuate




Underexpression of Deleted in liver cancer 2 DLC2 is associated with overexpression of RhoA and poor prognosis in hepatocellular carcinoma - Download this document for free, or read online. Document in PDF available to download.

BMC Cancer

, 8:205

First Online: 23 July 2008Received: 01 January 2008Accepted: 23 July 2008DOI: 10.1186-1471-2407-8-205

Cite this article as: Xiaorong, L., Wei, W., Liyuan, Q. et al. BMC Cancer 2008 8: 205. doi:10.1186-1471-2407-8-205

Abstract

BackgroundDLC2, a unique RhoGAP, has been recently identified as a tumor suppressor gene in hepatocellular carcinoma HCC. However, the expression of DLC2 protein, and its relationship with RhoA in clinical hepatocellular carcinoma have not been studied. The aim of this study was to investigate the DLC2 protein expression and its correlation with expression of RhoA, as well as to evaluate the prognostic value of DLC2 for HCC patients.

MethodsWestern blot and immunohistochemical staining were employed to detect DLC2 protein expression in 128 HCC specimens. The correlation between DLC2 protein expression and clinicopathologic outcome, and prognostic value of DLC2 for HCC patients were analyzed.

ResultsHCC tissues revealed significantly lower level of DLC2 protein than pericarcinomatous liver tissues PCLT. There was significant correlation between underexpression of DLC2 protein and cell differentiation. Meanwhile, underexpression of DLC2 protein was correlated with overexression of RhoA. Furthermore, HCC Patients with DLC2-negative expression showed a significantly poorer prognosis than those with DLC2-positve expression.

ConclusionOur data strongly suggested that decreased DLC2 expression in HCC correlates with cell differentiation of HCC and overexpression of RhoA, underexpression of DLC2 is associated with poor prognosis in HCC patients.

Electronic supplementary materialThe online version of this article doi:10.1186-1471-2407-8-205 contains supplementary material, which is available to authorized users.

Download fulltext PDF



Author: Li Xiaorong - Wu Wei - Qian Liyuan - Yang Kaiyan

Source: https://link.springer.com/







Related documents