Overcoming tumor immune evasion with an unique arbovirusReport as inadecuate

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Journal of Translational Medicine

, 13:3

First Online: 16 January 2015Received: 20 September 2014Accepted: 01 December 2014DOI: 10.1186-s12967-014-0349-0

Cite this article as: Lyday, B., Chen, T., Kesari, S. et al. J Transl Med 2015 13: 3. doi:10.1186-s12967-014-0349-0


Combining dendritic cell vaccination with the adjuvant effect of a strain of dengue virus may be a way to overcome known tumor immune evasion mechanisms. Dengue is unique among viruses as primary infections carry lower mortality than the common cold, but secondary infections carry significant risk of hypovolemic shock. While current immuno-therapies rely on a single axis of attack, this approach combines physiological hyperthermic reduction of tumor perfusion, immunological activation of effector cells of the adaptive and innate immune system, and apoptosis-inducing pathways sTRAIL to destroy tumor cells. The premise of using multiple mechanisms of action in synergy with a decline in the ability of the tumor cells to employ resistance methods suggests the potential of this combination approach in cancer immunotherapy.

KeywordsDeath Receptors Dendritic cell Dengue fever Hyperthermia Immunotherapy Immune Evasion Spontaneous Regression Soluble TRAIL  Download fulltext PDF

Author: Bruce Lyday - Tony Chen - Santosh Kesari - Boris Minev

Source: https://link.springer.com/

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