Magnetically Triggered Monodispersed Nanocomposite Fabricated by Microfluidic Approach for Drug DeliveryReport as inadecuate




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International Journal of Polymer Science - Volume 2016 2016, Article ID 1219469, 8 pages -

Research Article

Computer, Electrical and Mathematical Sciences and Engineering Division, King Abdullah University of Science and Technology, P.O. Box 4700, Thuwal 23955-6900, Saudi Arabia

Physical Sciences and Engineering Division, King Abdullah University of Science and Technology, Thuwal 23955-6900, Saudi Arabia

School of Engineering, University of British Columbia, 3333 University Way, Kelowna, BC, Canada V1V 1V7

Received 19 February 2016; Revised 24 April 2016; Accepted 4 May 2016

Academic Editor: Kai Chen

Copyright © 2016 O. Yassine et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Responsive microgel polyN-isopropylacrylamide or PNIPAM is a gel that can swell or shrink in response to external stimuli temperature, pH, etc

In this work, a nanocomposite gel is developed consisting of PNIPAM and magnetic iron oxide nanobeads for controlled release of liquids like drugs upon exposure to an alternating magnetic field. Microparticles of the nanocomposite are fabricated efficiently with a monodisperse size distribution and a diameter ranging from 20 to 500 µm at a rate of up to 1 kHz using a simple and inexpensive microfluidic system. The nanocomposite is heated through magnetic losses, which is exploited for a remotely stimulated liquid release. The efficiency of the microparticles for controlled drug release applications is tested with a solution of Rhodamine B as a liquid drug model. In continuous and pulsatile mode, a release of 7% and 80% was achieved, respectively. Compared to external thermal actuation that heats the entire surrounding or embedded heaters that need complex fabrication steps, the magnetic actuation provides localized heating and is easy to implement with our microfluidic fabrication method.





Author: O. Yassine, E. Q. Li, A. Alfadhel, A. Zaher, M. Kavaldzhiev, S. T. Thoroddsen, and J. Kosel

Source: https://www.hindawi.com/



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