The PPARγ2 Pro12Ala variant is protective against progression of nephropathy in people with type 2 diabetesReport as inadecuate




The PPARγ2 Pro12Ala variant is protective against progression of nephropathy in people with type 2 diabetes - Download this document for free, or read online. Document in PDF available to download.

Journal of Translational Medicine

, 13:85

First Online: 12 March 2015Received: 09 October 2014Accepted: 27 February 2015DOI: 10.1186-s12967-015-0448-6

Cite this article as: Lapice, E., Monticelli, A., Cocozza, S. et al. J Transl Med 2015 13: 85. doi:10.1186-s12967-015-0448-6

Abstract

ObjectiveCross-sectional studies suggest the association between diabetic nephropathy and the PPARγ2 Pro12Ala polymorphism of the peroxisome proliferator-activated receptor γ2 PPARγ2. Prospective data are limited to microalbuminuria and no information on renal function is available to date. The present study evaluates the association between the Pro12Ala polymorphism of PPARγ2 and the progression of albuminuria and decay in glomerular filtration rate GFR in type 2 diabetes.

Patients and measurementsWe studied 256 patients with an average 5-year follow-up. Among others, urinary albumin excretion rate UAER was measured on spot sample, GFR was estimated with the CKD-EPI Equation.

ResultsBaseline UAER and GFR were similar for carriers or non-carriers of the polymorphism. At follow-up no significant changes from baseline were observed for UAER or eGFR in carriers of the Pro12Ala polymorphism whereas a significant increase in UAER 17 11.3-37.9 versus 24.5 13.8-49.9 μg-mg, p < 0.006 and a significant reduction in the eGFR 82.8 ± 14.5 versus 80.3 ± 17.3 ml-min-1.73, m p = 0.02, were observed in non carriers of the Pro12Ala polymorphism. Progression of nephropathy - defined according to a combined end point of UAER and eGFR- i.e. doubling of baseline UAER to at least 100 μg-mg, or new onset microalbuminuria, or progression from micro to macroalbuminuria, or 25% reduction of eGFR, or annualized eGFR decline >3 ml-min-year - was significantly less frequent in Ala carriers than non carriers 11.4% vs 35.8%; p < 0.01; HR adjusted for baseline age, AER, eGFR, HbA1c, diabetes duration and blood pressure was 0.32 0.12-0.80.

ConclusionsThis study found that among patients with type 2 diabetes, the PPARγ2 Pro12Ala polymorphism is protective against progression of nephropathy and decay of renal function independent of major confounders.

KeywordsNephropathy PPAR-gamma polymorphism Type 2 diabetes  Download fulltext PDF



Author: Emanuela Lapice - Antonella Monticelli - Sergio Cocozza - Michele Pinelli - Sara Cocozza - Dario Bruzzese - Gabriele Riccar

Source: https://link.springer.com/







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