Adipo-cytokines in atherosclerotic secretomes: increased visfatin levels in unstable carotid plaqueReport as inadecuate




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BMC Cardiovascular Disorders

, 16:149

Hypertension and Cardiovascular Risk

Abstract

BackgroundNovel pro-inflammatory and anti-inflammatory derivatives from adipose tissue, known as adipokines, act as metabolic factors. The aim of this study was to analyse the secreted expression of different adipo-cytokines in secretomes of unstable carotid atherosclerotic plaque versus non-atherosclerotic mammary artery.

MethodsWe evaluated the secretion levels of adiponectin, visfatin, lipocalin-2, resistin, IL-6 and TNFR2 by ELISA in human secretomes from cultured unstable carotid atherosclerotic plaque n = 18 and non-atherosclerotic mammary artery n = 13. We also measured visfatin serum levels in patients suffering from atherosclerosis and in a serum cohort of healthy subjects n = 16.

ResultsWe found that visfatin levels were significantly increased in unstable carotid atherosclerotic plaque secretome than in non-atherosclerotic mammary artery secretome. No differences were found with regard the other adipo-cytokines studied. Regarding visfatin circulating levels, there were no differences between unstable carotid atherosclerotic plaque and non-atherosclerotic mammary artery group. However, these visfatin levels were increased in comparison to serum cohort of healthy subjects.

ConclusionsOf all the adipo-cytokines analysed, only visfatin showed increased levels in secretomes of unstable carotid atherosclerotic plaque. Additional human studies are needed to clarify the possible role of visfatin as prognostic factor of unstable carotid atherosclerotic plaque.

KeywordsAtheroma plaque Secretome Visfatin Atherosclerosis Adipo-cytokines  Download fulltext PDF



Author: Teresa Auguet - Gemma Aragonès - Esther Guiu-Jurado - Alba Berlanga - Marta Curriu - Salomé Martinez - Ajla Alibalic - Ca

Source: https://link.springer.com/







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