Clinicopathologic significance of HIF-1α, p53, and VEGF expression and preoperative serum VEGF level in gastric cancerReport as inadecuate




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BMC Cancer

, 8:123

First Online: 01 May 2008Received: 11 January 2008Accepted: 01 May 2008DOI: 10.1186-1471-2407-8-123

Cite this article as: Oh, S.Y., Kwon, HC., Kim, SH. et al. BMC Cancer 2008 8: 123. doi:10.1186-1471-2407-8-123

Abstract

BackgroundHypoxia influences tumor growth by inducing angiogenesis and genetic alterations. Hypoxia-inducible factor 1α HIF-1α, p53, and vascular endothelial growth factor VEGF are all important factors in the mechanisms inherent to tumor progression. In this work, we have investigated the clinicopathologic significance of HIF-1α, p53, and VEGF expression and preoperative serum VEGF sVEGF level in gastric cancer.

We immunohistochemically assessed the HIF-1α, p53, and VEGF expression patterns in 114 specimens of gastric cancer. Additionally, we determined the levels of preoperative serum VEGF sVEGF.

ResultsThe positive rates of p53 and HIF-1α diffuse, deep, intravascular pattern were 38.6% and 15.8%, respectively. The VEGF overexpression rate was 57.9%. p53 and HIF-1α were correlated positively with the depth of invasion P = 0.015, P = 0.001, respectively. Preoperative sVEGF and p53 levels were correlated significantly with lymph node involvement P = 0.010, P = 0.040, respectively. VEGF overexpression was more frequently observed in the old age group ≥ 60 years old and the intestinal type P = 0.013, P = 0.014, respectively. However, correlations between preoperative sVEGF level and tissue HIF-1α, VEGF, and p53 were not observed. The median follow-up duration after operation was 24.5 months. HIF-1α was observed to be a poor prognostic factor of disease recurrence or progression P = 0.002.

Conclusionp53, HIF-1α and preoperative sVEGF might be markers of depth of invasion or lymph node involvement. HIF-1α expression was a poor prognostic factor of disease recurrence or progression in patients with gastric cancers.

Electronic supplementary materialThe online version of this article doi:10.1186-1471-2407-8-123 contains supplementary material, which is available to authorized users.

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Author: Sung Yong Oh - Hyuk-Chan Kwon - Sung-Hyun Kim - Jin Seok Jang - Min Chan Kim - Kyeong Hee Kim - Jin-Yeong Han - Chung 

Source: https://link.springer.com/







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