Childhood adiposity trajectories are associated with late adolescent blood pressure: birth to twenty cohortReport as inadecuate




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BMC Public Health

, 16:665

Chronic Disease epidemiology

Abstract

BackgroundElevated blood pressure in childhood is a risk factor for adult hypertension which is a global health problem. Excess adiposity in childhood creates a predisposition to develop adult hypertension. Our aim was to explore distinct sex-specific adiposity trajectories from childhood to late adolescence and examined their association with blood pressure.

MethodsLatent Class Growth Mixture Modeling LCGMM on longitudinal data was used to derive sex-specific and distinct body mass index BMI: kg-m trajectories. We studied 1824 black children boys = 877, girls = 947 from the Birth to Twenty Bt20 cohort from Soweto, South Africa, and obtained BMI measures at ages 5 through 18 years. Participants with at least two age-point BMI measures, were included in the analysis. Analysis of variance ANOVA, chi-square test, multivariate linear and standard logistic regressions were used to test study characteristics and different associations.

ResultsWe identified three 3 and four 4 distinct BMI trajectories in boys and girls, respectively. The overall prevalence of elevated blood pressure BP was 34.9 % 39.4 % in boys and 30.38 % in girls. Boys and girls in the early onset obesity or overweight BMI trajectories were more likely to have higher BP values in late adolescence. Compared to those in the normal weight BMI trajectory, girls in early onset obesity trajectories had an increased risk of elevated BP with odds ratio OR of 2.18 95 % confidence interval 1.31 to 4.20 and 1.95 1.01 to 3.77. We also observed the weak association for boys in early onset overweight trajectory, p-value = 0.18 and odds ratio of 2.39 0.67 to 8.57

ConclusionsDistinct weight trajectories are observed in black South African children from as early as 5 years. Early onset adiposity trajectories are associated with elevated BP in both boys and girls. It is important to consider individual patterns of early-life BMI development, so that intervention strategies can be targeted to at-risk individuals.

KeywordsBlood pressure Latent classes Latent class growth mixture modeling Body mass index trajectories Trajectories Hypertension Childhood adiposity Obesity  Download fulltext PDF



Author: Richard J. Munthali - Juliana Kagura - Zané Lombard - Shane A. Norris

Source: https://link.springer.com/







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