Effect of maternal gestational weight gain on offspring DNA methylation: a follow-up to the ALSPAC cohort studyReport as inadecuate




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BMC Research Notes

, 8:321

Medical Genomics

Abstract

BackgroundSeveral epidemiologic studies indicate that maternal gestational weight gain GWG influences health outcomes in offspring. Any underlying mechanisms have, however, not been established. A recent study of 88 children based on the Avon Longitudinal Study of Parents and Children ALSPAC cohort examined the methylation levels at 1,505 Cytosine-Guanine methylation CpG loci and found several to be significantly associated with maternal weight gain between weeks 0 and 18 of gestation. Since these results could not be replicated we wanted to examine associations between 0 and 18 week GWG and genome-wide methylation levels using the Infinium HumanMethylation450 BeadChip 450K platform on a larger sample size, i.e. 729 newborns sampled from the Norwegian Mother and Child Cohort Study MoBa.

ResultsWe found no CpG loci associated with 0–18 week GWG after adjusting for the set of covariates used in the ALSPAC study i.e. child’s sex and maternal age and for multiple testing q > 0.9, both 1,505 and 473,731 tests. Hence, none of the CpG loci linked with the genes found significantly associated with 0–18 week GWG in the ALSPAC study were significant in our study.

ConclusionsThe inconsistency in the results with the ALSPAC study with regards to the 0–18 week GWG model may arise for several reasons: sampling from different populations, dissimilar methylome coverage, sample size and-or false positive findings.

Jon Bohlin and Bettina K Andreassen contributed equally to this work

Electronic supplementary materialThe online version of this article doi:10.1186-s13104-015-1286-6 contains supplementary material, which is available to authorized users.

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Author: Jon Bohlin - Bettina K Andreassen - Bonnie R Joubert - Maria C Magnus - Michael C Wu - Christine L Parr - Siri E Håb

Source: https://link.springer.com/







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