Efficacy of weekly docetaxel in locally advanced cardiac angiosarcomaReport as inadecuate




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BMC Research Notes

, 8:325

Cancer

Abstract

BackgroundPrimary cardiac angiosarcoma is extremely aggressive; however, it is often misdiagnosed because of its rarity. For locally advanced tumors, doxorubicin-based chemotherapy regimens are the standard of treatment, even if the gain in term of progression-free survival is limited and is no longer than 5 months.

Case presentationWe report the case of a Caucasian 23-year-old man with locally advanced cardiac angiosarcoma who underwent radical surgical resection after a prolonged response to weekly docetaxel and complementary radiotherapy.

ConclusionCombined treatment with weekly docetaxel and radiotherapy may be a valid alternative for the treatment of locally advanced cardiac angiosarcoma; the combination can lead to radical surgical resections, avoiding the cumulative cardiotoxicity of antracycline-based regimens.

KeywordsAngiosarcoma Soft tissue sarcoma Taxanes Docetaxel Cardiac tumors AbbreviationsECGelectrocardiogram

CTcomputed tomography

NMRnuclear magnetic resonance

PETpositron emission tomography

cGycentigray

SUVstandardized uptake value

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Author: Santino Minichillo - Maria Abbondanza Pantaleo - Margherita Nannini - Fabio Coccolo - Lidia Gatto - Guido Biasco - Giovanni

Source: https://link.springer.com/







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