Familial hepatocellular carcinoma in an endemic area: two case reportsReport as inadecuate




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BMC Research Notes

, 8:415

Cancer

Abstract

BackgroundHepatocellular carcinoma HCC usually affects patients aged 50–70 years but earlier onset 25–40 years may occur in hepatitis B endemic areas. 70–90 % of HCC develop on a background of cirrhosis. However, hepatitis B virus is directly oncogenic and can cause HCC in the absence of cirrhosis. This may represent a major cause of death from late diagnosis in resource-limited areas.

Case presentationWe report a black African family in which clinical diagnosis of HCC was made on two male siblings in the south west region of Cameroon.

ConclusionsThe highest risk for HCC may occur in families in which a hereditary component may be acting in concert with hepatitis B virus. In all cases of HCC, it is important to screen all first degree relatives to detect early and asymptomatic disease.

KeywordsHepatocellular carcinoma Fibrolamellar variant Hepatitis B Genetics AbbreviationsHCChepatocellular carcinoma

FHCCfibrolamellar hepatocellular carcinoma

HepBsAghepatitis B surface antigen

HCV Abhepatitis C antibody

HBDNAhepatitis B DNA

HBcAbhepatitis B core antibody

Electronic supplementary materialThe online version of this article doi:10.1186-s13104-015-1366-7 contains supplementary material, which is available to authorized users.

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Author: Elroy P. Weledji - Dickson S. Nsagha - George Enoworock - Maurice Mouladje

Source: https://link.springer.com/







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