Endometrial regenerative cells: A novel stem cell populationReport as inadecuate




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Journal of Translational Medicine

, 5:57

First Online: 15 November 2007Received: 26 September 2007Accepted: 15 November 2007DOI: 10.1186-1479-5876-5-57

Cite this article as: Meng, X., Ichim, T.E., Zhong, J. et al. J Transl Med 2007 5: 57. doi:10.1186-1479-5876-5-57

Abstract

Angiogenesis is a critical component of the proliferative endometrial phase of the menstrual cycle. Thus, we hypothesized that a stem cell-like population exist and can be isolated from menstrual blood. Mononuclear cells collected from the menstrual blood contained a subpopulation of adherent cells which could be maintained in tissue culture for >68 doublings and retained expression of the markers CD9, CD29, CD41a, CD44, CD59, CD73, CD90 and CD105, without karyotypic abnormalities. Proliferative rate of the cells was significantly higher than control umbilical cord derived mesenchymal stem cells, with doubling occurring every 19.4 hours. These cells, which we termed -Endometrial Regenerative Cells- ERC were capable of differentiating into 9 lineages: cardiomyocytic, respiratory epithelial, neurocytic, myocytic, endothelial, pancreatic, hepatic, adipocytic, and osteogenic. Additionally, ERC produced MMP3, MMP10, GM-CSF, angiopoietin-2 and PDGF-BB at 10–100,000 fold higher levels than two control cord blood derived mesenchymal stem cell lines. Given the ease of extraction and pluripotency of this cell population, we propose ERC as a novel alternative to current stem cells sources.

Electronic supplementary materialThe online version of this article doi:10.1186-1479-5876-5-57 contains supplementary material, which is available to authorized users.

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Author: Xiaolong Meng - Thomas E Ichim - Jie Zhong - Andrea Rogers - Zhenglian Yin - James Jackson - Hao Wang - Wei Ge - Vladimir

Source: https://link.springer.com/







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