Adiponectin, Leptin, and Resistin in Asthma: Basic Mechanisms through Population StudiesReport as inadecuate




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Journal of AllergyVolume 2013 2013, Article ID 785835, 15 pages

Review Article

School of Medicine, Department of Medicine, University of New Mexico, MSC 10 5550, Albuquerque, NM 87131, USA

Department of Environmental Health, Molecular and Integrative Physiological Sciences Program, Harvard School of Public Health, 665 Huntington Avenue, Building I, Room 307, Boston, MA 02115, USA

Received 28 February 2013; Revised 3 September 2013; Accepted 5 September 2013

Academic Editor: Balaram Ghosh

Copyright © 2013 Akshay Sood and Stephanie A. Shore. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Adipokines, factors produced by adipose tissue, may be proinflammatory such as leptin and resistin or anti-inflammatory such as adiponectin. Effects of these adipokines on the lungs have the potential to evoke or exacerbate asthma. This review summarizes basic mechanistic data through population-based and clinical studies addressing the potential role of adipokines in asthma. Augmenting circulating concentrations of adiponectin attenuates allergic airway inflammation and airway hyperresponsiveness in mice. Murine data is supported by human data that suggest that low serum adiponectin is associated with greater risk for asthma among women and peripubertal girls. Further, higher serum total adiponectin may be associated with lower clinical asthma severity among children and women with asthma. In contrast, exogenous administration of leptin results in augmented allergic airway hyperresponsiveness in mice. Alveolar macrophages obtained from obese asthmatics are uniquely sensitive to leptin in terms of their potential to augment inflammation. Consistent with this basic mechanistic data, epidemiologic studies demonstrate that higher serum leptin is associated with greater asthma prevalence and-or severity and that these associations may be stronger among women, postpubertal girls, and prepubertal boys. The role of adipokines in asthma is still evolving, and it is not currently known whether modulation of adipokines may be helpful in asthma prevention or treatment.





Author: Akshay Sood and Stephanie A. Shore

Source: https://www.hindawi.com/



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