Effects of exercise on neuromuscular junction components across age: systematic review of animal experimental studiesReport as inadecuate




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BMC Research Notes

, 8:713

Neuroscience

Abstract

BackgroundDuring almost one-third of our life, maturation of the nervous system promotes strength and muscle mass increase. However, as age advances, the nervous system begins to suffer a slow and continue reduction of its functions. Neuromuscular junction NMJ is one of the structures of which change due to aging process. Physical training leads to significant adjustments in NMJs of young and aged animals. Nevertheless, studies that aimed to investigate this effect have, in many cases, methodological variables that may have some influence on the result. Thus, this study aimed to carry out a systematic review about the effects of exercise training on the NMJ compartments of young, adult and aged animals.

ResultsWe searched PubMed, Google Scholar, Science Direct, Scielo and Lilacs databases for animal experimental studies that studied exercise effects on the NMJs components across age. After inclusion and exclusion criteria, we included nine articles in systematic review and two for meta-analysis young-adult NMJ.

ConclusionsWe identified that exercise training cause NMJ hypertrophy on young animals and NMJ compression on aged ones. However, many methodological issues such as age, skeletal muscle and fibers type, and type of exercise and training protocol might influence the results.Open image in new windowGraphical abstract:Flow gram is actually to be show at results section as Fig 1

KeywordsMyoneural junction Strength training Aerobic training Myofibers AbbreviationsNMJneuromuscular junction

AChRacetylcholine receptor

EDLextensor digitorum longus

IGF-1insulin like growth factor-1

CGRPcalcitonin gene-related peptide

GDNFglial cell line-derived neurotrophic factor

NT-4neurotrophin 4

BDNFbrain-derived neurotrophic factor

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Author: Walter Krause Neto - Adriano Polican Ciena - Carlos Alberto Anaruma - Romeu Rodrigues de Souza - Eliane Florencio Gama

Source: https://link.springer.com/







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