Low-grade inflammation may moderate the effect of behavioral treatment for chronic pain in adultsReport as inadecuate




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Journal of Behavioral Medicine

, Volume 39, Issue 5, pp 916–924

First Online: 28 July 2016Received: 31 March 2016Accepted: 07 July 2016DOI: 10.1007-s10865-016-9769-z

Cite this article as: Lasselin, J., Kemani, M.K., Kanstrup, M. et al. J Behav Med 2016 39: 916. doi:10.1007-s10865-016-9769-z

Abstract

The purpose of the present pilot study was to explore the moderating role of basal inflammation on the effects of behavioral pain treatment in 41 patients with long-standing pain. Baseline pro-inflammatory status moderated behavioral treatment outcomes: higher pre-treatment levels of Tumor Necrosis Factor TNF-α and Interleukin IL-6 were related to less improvement in pain intensity, psychological inflexibility and in mental health-related quality of life. The treatment outcomes improved in the subgroup that had low levels of pro-inflammatory cytokines at baseline, while the subjects with higher pro-inflammatory status did not. Altogether, results indicate that low-grade inflammation may influence the behavioral treatment outcomes and provide a possible explanation of the heterogeneity in treatment response.

KeywordsChronic pain Cognitive behavioral therapy CBT Psychological inflexibility Chronic low-grade inflammation Cytokines Treatment responders Julie Lasselin and Mike K Kemani have contributed equally to this work.

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Author: Julie Lasselin - Mike K. Kemani - Marie Kanstrup - Gunnar L. Olsson - John Axelsson - Anna Andreasson - Mats Lekander - R

Source: https://link.springer.com/



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