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European Journal of Medical Research

, 21:40

First Online: 13 October 2016Received: 04 August 2016Accepted: 06 October 2016DOI: 10.1186-s40001-016-0234-9

Cite this article as: Heidegger, I., Tulchiner, G., Schäfer, G. et al. Eur J Med Res 2016 21: 40. doi:10.1186-s40001-016-0234-9

Abstract

BackgroundSmall cell bladder cancer SCBC is an aggressive subtype accounting for less than 1 % of all bladder malignancies associated with rapid progression, early metastases formation and high mortality rates.

Case presentationWe present an unusual long term disease free survival of a 60 year-old man who was diagnosed with SCBC two and a half years ago. He underwent four cycles of cisplatin-etoposide chemotherapy as well as a prophylactic whole-brain radiotherapy followed by a radical cystoprostatectomy and ileal neobladder with extended pelvic lymphadenectomy. Since 33 months the patient is now recurrence-free.

ConclusionIn this case report, we were able to show that early multimodal therapy results in long term disease free survival, thus we highly recommend neoadjuvant chemotherapy as a part of multimodal management of a primary metastases-free, localized and surgically resectable SCBC.

KeywordsSmall cell bladder cancer Multimodal therapy Neoadjuvant chemotherapy Disease free survival AbbreviationsOSoverall survival

PET-CTpositron emission tomography-computed tomography

MRTmagnet resonance tomography

SCBCsmall cell bladder cancer

WBRTwhole brain radiotherapy

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Author: Isabel Heidegger - Gennadi Tulchiner - Georg Schäfer - Wolfgang Horninger - Renate Pichler

Source: https://link.springer.com/







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