Characteristics of men responding to an invitation to undergo testing for prostate cancer as part of a randomised trialReport as inadecuate




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Trials

, 17:497

First Online: 13 October 2016Received: 11 May 2016Accepted: 24 September 2016DOI: 10.1186-s13063-016-1624-6

Cite this article as: Walsh, E.I., Turner, E.L., Lane, J.A. et al. Trials 2016 17: 497. doi:10.1186-s13063-016-1624-6

Abstract

BackgroundSociodemographic characteristics are associated with participating in cancer screening and trials. We compared the characteristics of those responding with those not responding to a single invitation for prostate-specific antigen PSA testing for prostate cancer as part of the Cluster randomised triAl of PSA testing for Prostate cancer CAP.

MethodsAge, rurality and deprivation among 197,763 men from 271 cluster-randomised primary care centres in the UK were compared between those responding n = 90,300 and those not responding n = 100,953 to a prostate cancer testing invitation.

ResultsThere was little difference in age between responders and nonresponders. Responders were slightly more likely to come from urban rather than rural areas and were slightly less deprived than those who did not respond.

ConclusionThese data indicate similarities in age and only minor differences in deprivation and urban location between responders and nonresponders. These differences were smaller, but in the same direction as those observed in other screening trials.

Trial registrationISRCTN92187251. Registered on 29 November 2004.

KeywordsProstate cancer Screening Randomised controlled trial PSA testing Prostate specific antigen testing AbbreviationsCAGConfidentiality Advisory Group

CAPCluster randomised triAl of PSA testing for Prostate cancer

CIConfidence interval

GPGeneral practitioner

HVEHealthy Volunteer Effect

IMDIndex Multiple Deprivation

IQRInterquartile range

MRECMulticentre Research Ethics Committee

OROdds ratio

PCaProstate cancer

PIAGPatient Information Advisory Group

ProtecTProstate testing for cancer and treatment

PSAProstate-specific antigen

RCTsRandomised controlled trials

RUACRural and Urban Area Classification

SDStandard deviation

UKNSCUK National Screening Committee

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Author: Eleanor I. Walsh - Emma L. Turner - J. Athene Lane - Jenny L. Donovan - David E. Neal - Freddie C. Hamdy - Richard M.

Source: https://link.springer.com/







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