A Patient-Specific Foot Model for the Estimate of Ankle Joint Forces in Patients with Juvenile Idiopathic ArthritisReport as inadecuate




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Annals of Biomedical Engineering

, Volume 44, Issue 1, pp 247–257

First Online: 15 September 2015Received: 29 April 2015Accepted: 04 September 2015DOI: 10.1007-s10439-015-1451-z

Cite this article as: Prinold, J.A.I., Mazzà, C., Di Marco, R. et al. Ann Biomed Eng 2016 44: 247. doi:10.1007-s10439-015-1451-z

Abstract

Juvenile idiopathic arthritis JIA is the leading cause of childhood disability from a musculoskeletal disorder. It generally affects large joints such as the knee and the ankle, often causing structural damage. Different factors contribute to the damage onset, including altered joint loading and other mechanical factors, associated with pain and inflammation. The prediction of patients’ joint loading can hence be a valuable tool in understanding the disease mechanisms involved in structural damage progression. A number of lower-limb musculoskeletal models have been proposed to analyse the hip and knee joints, but juvenile models of the foot are still lacking. This paper presents a modelling pipeline that allows the creation of juvenile patient-specific models starting from lower limb kinematics and foot and ankle MRI data. This pipeline has been applied to data from three children with JIA and the importance of patient-specific parameters and modelling assumptions has been tested in a sensitivity analysis focused on the variation of the joint reaction forces. This analysis highlighted the criticality of patient-specific definition of the ankle joint axes and location of the Achilles tendon insertions. Patient-specific detection of the Tibialis Anterior, Tibialis Posterior, and Peroneus Longus origins and insertions were also shown to be important.

KeywordsMusculoskeletal Sensitivity Lower-limb Foot OpenSim NMS-Builder Associate Editor K. A. Athanasiou oversaw the review of this article.

Electronic supplementary materialThe online version of this article doi:10.1007-s10439-015-1451-z contains supplementary material, which is available to authorized users.

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Author: Joe A. I. Prinold - Claudia Mazzà - Roberto Di Marco - Iain Hannah - Clara Malattia - Silvia Magni-Manzoni - Maurizio Pe

Source: https://link.springer.com/



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