Common NOD2-CARD15 variants are not associated with susceptibility or the clinicopathologic characteristics of sporadic colorectal cancer in Hungarian patientsReport as inadecuate




Common NOD2-CARD15 variants are not associated with susceptibility or the clinicopathologic characteristics of sporadic colorectal cancer in Hungarian patients - Download this document for free, or read online. Document in PDF available to download.

BMC Cancer

, 7:54

First Online: 27 March 2007Received: 18 October 2006Accepted: 27 March 2007DOI: 10.1186-1471-2407-7-54

Cite this article as: Lakatos, P.L., Hitre, E., Szalay, F. et al. BMC Cancer 2007 7: 54. doi:10.1186-1471-2407-7-54

Abstract

BackgroundEpidemiological observations suggest that cancer arises from chronically inflamed tissues. Inflammatory bowel disease IBD is a typical example as patients with longstanding IBD are at an increased risk for developing colorectal cancer CRC and mutations of the NOD2-CARD15 gene increase the risk for Crohn-s disease CD. Recently, NOD2-CARD15 has been associated with a risk for CRC in some studies, which stemmed from ethnically diverse populations. Our aim was to identify common NOD2-CARD15 mutations in Hungarian patients with sporadic CRC.

MethodsA total of 194 sporadic CRC patients m-f: 108-86, age at diagnosis of CRC: 63.2 ± 9.1 years old and 200 healthy subjects were included. DNA was screened for SNP8, SNP12 and SNP13 NOD2-CARD15 mutations by denaturing-HPLC and confirmed by direct sequencing.

ResultsNOD2-CARD15 mutations were found in 28 patients 14.4% and in 23 controls 11.5%, p = NS. Allele frequencies for SNP8-R702W 1.8% vs. 1.5% SNP12-G908R 1.8% vs. 1.8% and SNP13-3020insC 3.6% vs. 2.5% were also not statistically different between patients and controls. The clinicopathologic characteristics of CRC patients with or without NOD2-CARD15 mutations were not significantly different.

ConclusionOur results suggest that common NOD2-CARD15 mutations alone do not contribute to CRC risk in the Hungarian population.

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Author: Peter Laszlo Lakatos - Erika Hitre - Ferenc Szalay - Kerstin Zinober - Peter Fuszek - Laszlo Lakatos - Simon Fischer - Jan

Source: https://link.springer.com/







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