Extra-Articular Symptoms in Constellation with Selected Serum Cytokines and Disease Activity in SpondyloarthritisReport as inadecuate




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Mediators of Inflammation - Volume 2016 2016, Article ID 7617954, 7 pages -

Research Article

Department of Rheumatology, Internal Medicine and Geriatrics, Pomeranian Medical University in Szczecin, Unii Lubelskiej 1, 71-252 Szczecin, Poland

Independent Laboratory of Rheumatic Diagnostics, Pomeranian Medical University in Szczecin, Unii Lubelskiej 1, 71-252 Szczecin, Poland

Received 30 September 2016; Accepted 17 November 2016

Academic Editor: Yu Sun

Copyright © 2016 Hanna Przepiera-Będzak et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Objectives. In this study, we assessed the extra-articular symptoms in constellation with selected serum cytokines and disease activity in spondyloarthritis SpA. Patients and Methods. We studied 287 SpA patients: 131 had AS, 110 had PsA, and 46 had SAPHO. We assessed extra-articular symptoms in all cases. In 191 SpA patients, we measured serum interleukin-6 IL-6, interleukin-18 IL-18, interleukin-23 IL-23, endothelin-1 ET-1, vascular endothelial growth factor VEGF, and epidermal growth factor EGF. Results. Patients with acute anterior uveitis AAU had higher VAS , BADSDAI , ASDAS-ESR , CRP , IL-6 , and IL-18 levels. Patients with inflammatory bowel disease IBD had higher VAS , CRP , and IL-6 levels. Patients with skin psoriasis had lower VAS and BASDAI levels. Patients with psoriatic onycholysis had lower VAS , BASDAI , and CRP and higher IL-23 levels. Patients with PPP had lower BASDAI and higher ET-1 levels. Conclusions. SpA patients with increased serum IL-18 and decreased serum ET-1 had an increased risk of extra-articular symptoms. In SpA patients, increased disease activity was associated with an increased risk of AAU and IBD and a decreased risk of skin psoriasis, psoriatic onycholysis, and PPP.





Author: Hanna Przepiera-Będzak, Katarzyna Fischer, and Marek Brzosko

Source: https://www.hindawi.com/



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