Preoperative conventional chemoradiotherapy versus short-course radiotherapy with delayed surgery for rectal cancer: results of a randomized controlled trialReport as inadecuate




Preoperative conventional chemoradiotherapy versus short-course radiotherapy with delayed surgery for rectal cancer: results of a randomized controlled trial - Download this document for free, or read online. Document in PDF available to download.

BMC Cancer

, 16:927

Medical and radiation oncology

Abstract

BackgroundThere still is no evidence which neoadjuvant therapy regimen for stage II–III rectal cancer is superior. The aim of this study was to compare results achieved after long-course chemoradiotherapy CRT with short-term radiotherapy RT followed by delayed surgery.

MethodsA randomized trial was carried out between 2007–2013. One hundred fifty patients diagnosed with stage II–III rectal cancer were randomized into one of two neoadjuvant treatment arms: conventional chemoradiotherapy CRT and short-term radiotherapy RT followed by surgery after 6–8 weeks. Primary endpoints of this trial were downstaging and pathological complete response rate. Secondary endpoints were local recurrence rate and overall survival.

ResultsThe pathological complete response was found in 3 4.4% cases after RT and 8 11.1% after CRT P = 0.112. Downstaging stage 0 and I was observed in 21 30.9% cases in RT group vs. 27 37.5% cases in CRT group P = 0.409. Median follow-up time was 39.7 range 4.9–79.7 months. 3-years overall survival OS was 78% in RT group vs. 82.4% in CRT group P = 0.145, while disease-free survival DFS differed significantly – 59% in RT group vs. 75.1% in CRT group P = 0,022. Hazard ratio of cancer progression for RT patients was 1.93 95% CI: 1.08–3.43 compared to CRT patients.

ConclusionThree-years disease-free survival was better in CRT group comparing with RT group with no difference in overall survival.

Trial registrationhttp:-clinicaltrials.gov identifier NCT00597311. January 2008.

KeywordsRectal cancer Chemoradiotherapy AbbreviationsCRTLong-course chemoradiotherapy

CTComputerized tomography

DFSDisease-free survival

ERUSEndorectal ultrasound

MRIMagnetic resonance imaging

OSOverall survival

RTShort-term radiotherapy

Download fulltext PDF



Author: Tadas Latkauskas - Henrikas Pauzas - Laura Kairevice - Aleksandras Petrauskas - Zilvinas Saladzinskas - Rasa Janciauskiene -

Source: https://link.springer.com/







Related documents