Effects of the avermectin, MK-243, on ovary development and salivary gland degeneration in the ixodid tick, Amblyomma hebraeumReport as inadecuate




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Amblyomma hebraeum, 20-Hydroxyecdysone, MK-243, Ticks, Avermectin, Vitellogenesis

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Subject-Keyword: Amblyomma hebraeum 20-Hydroxyecdysone MK-243 Ticks Avermectin Vitellogenesis

Type of item: Journal Article Published

Language: English

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Description: Note: figures and tables appear at the end of the article.

Date created: 2003

DOI: doi:10.7939-R30G3H23C

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Rights: © 2003 Elsevier. This version of this article is open access and can be downloaded and shared. The original authors and source must be cited.





Author: Friesen, K. J. Suri, R. Kaufman, W. R.

Source: https://era.library.ualberta.ca/


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1 Effects of the avermectin, MK-243, on ovary development and salivary gland degeneration in the ixodid tick, Amblyomma hebraeum Kevin J.
Friesen, Reena Suri, and W.
Reuben Kaufman* Department of Biological Sciences, University of Alberta Edmonton, Alberta, Canada T6G 2E9 Short Title: Physiological effects of avermectin MK-243 in ticks *Author for correspondence: W.
Reuben Kaufman, Department of Biological Sciences, University of Alberta, Edmonton, Alberta, Canada T6G 2E9; Tel.
1-780-492-1279; Fax.
1-780-492-9234; E-mail: reuben.kaufman@ualberta.ca Submitted to Pesticide Biochemistry and Physiology, September 23, 2002. Revised May 30, 2003. 2 Abstract Injection of the avermectin analogue, MK-243, into engorged female Amblyomma hebraeum Koch resulted in reduced ovary weight, oocyte length, and ovary vitellin content.
There was no significant reduction in hemolymph vitellogenin concentration in MK-243 treated ticks.
Although MK-243 was previously shown to markedly reduce hemolymph 20E-concentration, injection of 20E, the vitellogenic hormone in this tick, did not reverse the effects of MK-243 on ovary development.
These data suggest that MK-243 may exert its inhibition of egg development more at the level of vitellogenin uptake than vitellogenin synthesis.
MK-243 also reversed salivary gland degeneration slightly, probably via its inhibitory effect on 20E-synthesis. Key Words: Avermectin, Vitellogenesis, 20-Hydroxyecdysone, Amblyomma hebraeum, MK-243, ticks 3 1.
Introduction In ixodid ticks, synthesis of the main yolk protein, vitellogenin (Vg), and its uptake by oocytes, begins within a few days of engorgement on a blood meal.
Until recently, little was known about the hormonal regulation of Vg-synthesis in ticks.
Current evidence strongly suggests that an ecdysteroid is the vitellogenic hormone in the ixodid ticks, Ixodes scapularis [1], Dermacentor variabilis [2], and Amblyomma hebraeum [3], and the argasid tick, Ornithodoros moubata [4].
In A. hebraeum, t...





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