A mass vaccination campaign targeting adults and children to prevent typhoid fever in Hechi; Expanding the use of Vi polysaccharide vaccine in Southeast China: A cluster-randomized trialReport as inadecuate




A mass vaccination campaign targeting adults and children to prevent typhoid fever in Hechi; Expanding the use of Vi polysaccharide vaccine in Southeast China: A cluster-randomized trial - Download this document for free, or read online. Document in PDF available to download.

BMC Public Health

, 5:49

First Online: 18 May 2005Received: 28 December 2004Accepted: 18 May 2005DOI: 10.1186-1471-2458-5-49

Cite this article as: Yang, J., Acosta, C.J., Si, G. et al. BMC Public Health 2005 5: 49. doi:10.1186-1471-2458-5-49

Abstract

BackgroundOne of the goals of this study was to learn the coverage, safety and logistics of a mass vaccination campaign against typhoid fever in children and adults using locally produced typhoid Vi polysaccharide PS and group A meningococcal PS vaccines in southern China.

MethodsThe vaccination campaign targeted 118,588 persons in Hechi, Guangxi Province, aged between 5 to 60 years, in 2003. The study area was divided into 107 geographic clusters, which were randomly allocated to receive one of the single-dose parenteral vaccines. All aspects regarding vaccination logistics, feasibility and safety were documented and systematically recorded. Results of the logistics, feasibility and safety are reported.

ResultsThe campaign lasted 5 weeks and the overall vaccination coverage was 78%. On average, the 30 vaccine teams gave immunizations on 23 days. Vaccine rates were higher in those aged ≤ 15 years 90% than in adolescents and young adults 70%. Planned mop-up activities increased the coverage by 17%. The overall vaccine wastage was 11%. The cold chain was maintained and documented. 66 individuals reported of adverse events out of all vaccinees, where fever 21%, malaise 19% and local redness 19% were the major symptoms; no life-threatening event occurred. Three needle-sharp events were reported.

ConclusionThe mass immunization proved feasible and safe, and vaccine coverage was high. Emphasis should be placed on: injection safety measures, community involvement and incorporation of mop-up strategies into any vaccination campaign. School-based and all-age Vi mass immunizations programs are potentially important public health strategies for prevention of typhoid fever in high-risk populations in southern China.

Electronic supplementary materialThe online version of this article doi:10.1186-1471-2458-5-49 contains supplementary material, which is available to authorized users.





Author: Jin Yang - Camilo J Acosta - Guo-ai Si - Jun Zeng - Cui-yun Li - Da-bin Liang - R Leon Ochiai - Anne-Laure Page - M Car

Source: https://link.springer.com/







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