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BMC Cardiovascular Disorders

, 4:20

First Online: 01 November 2004Received: 07 January 2004Accepted: 01 November 2004DOI: 10.1186-1471-2261-4-20

Cite this article as: Williams, F.M., Cherkas, L.F., Spector, T.D. et al. BMC Cardiovasc Disord 2004 4: 20. doi:10.1186-1471-2261-4-20

Abstract

BackgroundCertain conditions characterised by blood vessel occlusion or vascular spasm have been found to cluster together in epidemiological studies. However the biological causes for these associations remain controversial. This study used a classical twin design to examine whether these conditions are linked through shared environmental exposures or by a common underlying genetic propensity to vasospasm.

MethodsWe investigated the association between hypertension, migraine, Raynaud-s phenomenon and coronary artery disease in twins from a national register. Phenotype status was determined using a questionnaire and the genetic and environmental association between phenotypes was estimated through variance components analysis.

ResultsResponses were obtained from 2,204 individuals comprising 525 monozygotic and 577 dizygotic pairs. There was a significant genetic contribution to all four traits with heritabilities ranging from 0.34 to 0.64. Multivariate model-fitting demonstrated that a single common genetic factor underlies the four conditions.

ConclusionsWe have confirmed an association between hypertension, migraine, Raynaud-s phenomenon and coronary artery disease, and shown that a single genetic factor underlies them. The demonstration of a shared genetic factor explains the association between them and adds weight to the theory of an inherited predisposition to vasospasm.

Electronic supplementary materialThe online version of this article doi:10.1186-1471-2261-4-20 contains supplementary material, which is available to authorized users.





Author: Frances MK Williams - Lynn F Cherkas - Tim D Spector - Alex J MacGregor

Source: https://link.springer.com/







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